Introduction：Biotin is a water-soluble B-complex vitamin (vitamin B7) that is composed of an ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a coenzyme in the metabolism of fatty acids and leucine, and it plays a role in gluconeogenesis.
Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. It plays a role in the citric acid cycle, which is the process by which biochemical energy is generated during aerobic respiration. Biotin not only assists in various metabolic reactions but also helps to transfer carbon dioxide. Biotin may also be helpful in maintaining a steady blood sugar level.
Biotin deficiency is rare, because intestinal bacteria generally produce biotin in excess of the body's daily requirements.
Appearance: White crystalline needles
Molecular formula: C10H16N2O3S
Molecular weight: 244.31
CAS Number:58-85-5
Toxicity: Animal studies have indicated few, if any, effects due to toxic doses of biotin. This may provide evidence that both animals and humans could tolerate doses of at least an order of magnitude greater than each of their nutritional requirements. There are no reported cases of adverse effects from receiving high doses of the vitamin, particularly when used in the treatment of metabolic disorders causing sebhorrheic dermatitis in infants.
Uses:
Hair Problems
The signs and symptoms of biotin deficiency include hair loss that progresses in severity to include loss of eye lashes and eyebrows in severely deficient subjects.
Seborrheic Dermatitis
Children with a rare inherited metabolic disorder called phenylketonuria often develop skin conditions such as eczema and seborrheic dermatitis in areas of the body other than the scalp.
Diabetes
Diabetics may also benefit from biotin supplementation. In both insulin-dependent and non-insulin-dependent diabetes, supplementation with biotin can improve blood sugar control and help lower fasting blood glucose levels, in some studies the reduction in fasting glucose exceeded 50 percent.
Specification: USP32/EP6